Understanding how specific immune cells help repair lungs after inflammation
Official title: Reparative functions of human airspace macrophage subsets
Funded at National Jewish Health · NIH-10804314 · Data updated 2026-11-12
This study is looking at how different types of immune cells in the lungs help clean up and heal after inflammation, which could be really helpful for people recovering from lung issues like acute respiratory distress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $602,955 |
| NIH project number | 1R01HL168278-01A1 |
| Project ID | NIH-10804314 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have experienced acute respiratory distress or related lung inflammation.
✕Less likely to help
Patients with chronic lung conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of different types of airspace macrophages, which are immune cells in the lungs, in clearing dead cells and repairing lung tissue after inflammation. The study uses advanced techniques like single-cell RNA sequencing to analyze how these macrophages function and interact during the healing process. By identifying the unique roles of these macrophage subsets, the research aims to uncover how they contribute to lung health recovery following acute respiratory distress.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance lung repair mechanisms in patients suffering from acute respiratory distress syndrome.
How similar studies have gone: Previous studies have shown promise in understanding macrophage functions in lung repair, suggesting that this approach could yield valuable insights.
Where this research is happening
-
National Jewish Health
Denver, United States Active
Researchers
- Principal investigator: Mould, Kara J — National Jewish Health
- Study coordinator: Mould, Kara J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.