Understanding how specific genes are selected for smell in the brain
Defining the components of olfactory singular expression
This study is looking at how our sense of smell works by figuring out how certain genes are picked to help our nose detect different odors, which could help us understand brain issues that affect our sense of smell.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hunter College NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11009924 on NIH RePORTER |
What this research studies
This research investigates how certain genes responsible for our sense of smell are chosen for expression in sensory neurons. By focusing on the olfactory system, the study aims to uncover the mechanisms behind monoallelic expression, where each neuron activates only one of many possible odorant receptor genes. The researchers will conduct genetic experiments and biochemical analyses to identify the components involved in this selection process, which could enhance our understanding of gene regulation in the brain. Patients may benefit from insights gained into brain disorders related to olfactory dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with olfactory disorders or related neurological conditions.
Not a fit: Patients with no olfactory issues or unrelated neurological conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating brain disorders associated with olfactory dysfunction.
How similar studies have performed: While the specific approach of this research is novel, there have been successful studies exploring gene regulation in other contexts.
Where this research is happening
New York, United States
- Hunter College — New York, United States (Active)
Researchers
- Principal investigator: Feinstein, Paul — Hunter College
- Study coordinator: Feinstein, Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.