Understanding how specific genes and molecules influence heart development from stem cells
Transcriptional Factor SOX2, LncRNA HBL1, microRNA1 and PRC2 Epigenetic Complex Compose a Network to Orchestrate Cardiac Differentiation from Human Pluripotent Stem Cells
This study is looking at how certain genes and molecules work together to help develop a healthy heart from stem cells, which could lead to new ways to understand and treat heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10688201 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between various genetic factors and molecules that play a crucial role in the development of the human heart from pluripotent stem cells. By focusing on specific elements like transcription factors, long noncoding RNAs, and microRNAs, the study aims to uncover the unique genetic programs that govern human cardiogenesis. The approach involves analyzing how these components work together to influence heart cell differentiation and function, which could lead to better understanding and treatment of heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital heart defects or those interested in stem cell therapies for heart conditions.
Not a fit: Patients with fully developed hearts and no history of cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for congenital heart defects and other cardiovascular diseases by improving our understanding of heart development.
How similar studies have performed: Other research has shown success in understanding gene regulatory mechanisms in heart development, but this specific focus on human-specific factors is relatively novel.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Yang, Lei — Indiana University Indianapolis
- Study coordinator: Yang, Lei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.