Understanding how specific enzymes affect brain development and function
Official title: Dissecting Histone H3K4 Methylation Enzymes in Neuroplasticity
Funded at University of Michigan at Ann Arbor · NIH-11135539 · Data updated 2026-11-12
This study is looking at how certain enzymes in the brain help with learning and memory, and how they might be linked to conditions that affect brain development, with the hope that understanding these processes could lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 12, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $560,525 |
| NIH project number | 5R01MH133632-02 |
| Project ID | NIH-11135539 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurodevelopmental disorders, such as autism spectrum disorder, who may benefit from targeted therapies based on the findings.
✕Less likely to help
Patients with neurodevelopmental disorders not linked to the specific enzymes being studied may not receive direct benefits from this research.
What this research studies
This research investigates the role of histone H3K4 methylation enzymes in the brain, focusing on how they influence neuroplasticity and cognitive development. By examining the functions of these enzymes, which are crucial for maintaining the balance of neuronal activity, the research aims to uncover their contributions to neurodevelopmental disorders. Patients may benefit from insights gained about how these enzymes affect brain signaling and behavior, potentially leading to new therapeutic strategies. The study employs advanced techniques in cellular imaging and signaling to analyze the effects of these enzymes in various brain cell types.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodevelopmental disorders by enhancing our understanding of brain function and plasticity.
How similar studies have gone: Previous research has shown promising results in understanding the role of chromatin regulators in brain function, indicating that this approach has potential for significant discoveries.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Iwase, Shigeki — University of Michigan at Ann Arbor
- Study coordinator: Iwase, Shigeki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.