Understanding how specific contexts affect the action of oxazolidinone antibiotics
Official title: Elucidating the role of context-specificity in oxazolidinone mechanism of action
Funded at University of California, San Francisco · NIH-10827332 · Data updated 2026-11-12
This study is looking at how certain antibiotics work to fight tough bacterial infections that don't respond to regular treatments, with the hope of finding better options for patients dealing with these resistant infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $45,909 |
| NIH project number | 1F31AI181568-01 |
| Project ID | NIH-10827332 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from infections caused by multidrug-resistant bacteria.
✕Less likely to help
Patients with infections caused by bacteria that are not resistant to current antibiotics may not benefit from this research.
What this research studies
This research investigates how oxazolidinone antibiotics, which are crucial for treating multidrug-resistant bacterial infections, work in different contexts. By using advanced techniques like ribosome profiling and cryo-electron microscopy, the study aims to uncover the specific mechanisms that allow these antibiotics to inhibit bacterial translation. The goal is to enhance our understanding of antibiotic resistance and develop improved treatments that can overcome these resistance mechanisms. Patients may benefit from new antibiotics that are more effective against resistant infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antibiotics that can combat resistant bacterial infections.
How similar studies have gone: Other research has shown promise in understanding antibiotic mechanisms, but this specific approach to oxazolidinones is relatively novel.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kleinman, Jordan Isabelle — University of California, San Francisco
- Study coordinator: Kleinman, Jordan Isabelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.