Understanding how specific brain cells develop and connect
Molecular and cellular mechanisms governing interneuron development and connectivity
This study is looking at special brain cells called chandelier cells that help keep our brain's activity balanced, and it's for anyone interested in understanding how problems with these cells might relate to conditions like schizophrenia and autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-10558482 on NIH RePORTER |
What this research studies
This research investigates the development and connectivity of chandelier cells, a type of inhibitory neuron that plays a crucial role in regulating the activity of excitatory neurons in the brain. By using advanced techniques like in utero electroporation and RNA interference, the study aims to uncover the molecular mechanisms that govern how these cells connect to excitatory neurons. This knowledge could help explain the underlying causes of brain disorders linked to dysfunctional neuronal circuits, such as schizophrenia and autism spectrum disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with brain disorders such as schizophrenia or autism spectrum disorder.
Not a fit: Patients with brain disorders not related to the connectivity of chandelier cells may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for brain disorders associated with impaired neuronal connectivity.
How similar studies have performed: Other research has shown success in understanding neuronal connectivity and its implications for brain disorders, making this approach promising.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Van Aelst, Linda — Cold Spring Harbor Laboratory
- Study coordinator: Van Aelst, Linda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.