Understanding how specific brain cells affect eating and nausea
Official title: Defining roles for area postrema neuron cell types in food intake and nausea
Funded at University of Michigan at Ann Arbor · NIH-11016971 · Data updated 2026-11-12
This study is looking at how different types of brain cells in a specific area help control hunger and feelings of nausea, with the goal of finding better ways to treat obesity while keeping side effects low.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | March 10, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $606,807 |
| NIH project number | 5R01DK132008-03 |
| Project ID | NIH-11016971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals struggling with obesity or related conditions such as type 2 diabetes.
✕Less likely to help
Patients who are not affected by obesity or do not experience nausea related to food intake may not benefit from this research.
What this research studies
This research investigates the role of different neuron types in the area postrema of the brain, which is involved in regulating food intake and nausea. By analyzing how these neurons respond to various signals related to nutrition and harmful substances, the study aims to uncover mechanisms that could lead to better obesity treatments. The researchers will use advanced techniques to identify and characterize the specific neuron populations and their functions in appetite control and nausea responses. This understanding could help in designing therapies that minimize adverse effects while promoting weight loss.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective obesity treatments that reduce nausea and improve patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding the brain's role in appetite regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Myers, Martin G — University of Michigan at Ann Arbor
- Study coordinator: Myers, Martin G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.