Understanding how specific areas of cells manage fat distribution and organelle formation
Official title: Roles of endoplasmic reticulum subdomains in regulating intracellular lipid distribution and organelle biogenesis
Funded at Ut Southwestern Medical Center · NIH-11049160 · Data updated 2026-11-12
This study is looking at a part of your cells called the endoplasmic reticulum, which helps keep your body's fats in balance and responds to stress; by understanding how it works and what happens when it doesn't, we hope to find new ways to help people with diabetes and heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $410,000 |
| NIH project number | 5R35GM153315-02 |
| Project ID | NIH-11049160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to lipid metabolism, such as adult-onset diabetes or cardiovascular diseases.
✕Less likely to help
Patients with conditions unrelated to lipid metabolism or organelle dysfunction may not benefit from this research.
What this research studies
This research investigates the endoplasmic reticulum (ER), a crucial part of cells that helps manage lipid metabolism and organelle formation. It focuses on distinct subdomains within the ER that interact with other organelles, which are essential for maintaining lipid balance and responding to cellular stress. By using innovative laboratory techniques, the research aims to uncover how these subdomains function and how their dysfunction can lead to diseases like diabetes and cardiovascular conditions. Patients may benefit from insights gained about lipid management in their cells, potentially leading to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for managing lipid-related diseases such as diabetes and cardiovascular disease.
How similar studies have gone: Previous research has shown promising results in understanding lipid metabolism and its implications for diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Prinz, William — Ut Southwestern Medical Center
- Study coordinator: Prinz, William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.