Understanding how special immune cells contribute to autoimmune and metabolic diseases
Uncovering the hidden universe of metabolite-specific T lymphocytes,using human multiorgan microphysiological systems.
This research explores how unique immune cells, called T lymphocytes, react to different body chemicals and contribute to conditions like autoimmune diseases and brittle diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11125797 on NIH RePORTER |
What this research studies
Many autoimmune and metabolic conditions are increasing, and we don't fully understand their origins or how to cure them. This project looks at a special type of immune cell, called an "unconventional" T lymphocyte, which can respond to non-protein signals in the body. These cells are thought to play a role in various disorders, including inflammatory bowel disease, type 1 diabetes, and autoimmune hepatitis. To better understand how these T cells affect our health, researchers are using advanced human organ models to study their behavior and interactions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on this work may seek individuals with autoimmune or metabolic conditions.
Not a fit: Patients not affected by autoimmune diseases or metabolic disorders would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of autoimmune and metabolic diseases, potentially paving the way for new treatments.
How similar studies have performed: The role of these 'unconventional' T lymphocytes in disease is a new and emerging area of exploration, with prior evidence suggesting their involvement in various disorders.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Trapecar, Martin — Johns Hopkins University
- Study coordinator: Trapecar, Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.