Understanding how Sox9 helps liver bile duct development and healing
Establishing Sox9 as a regulator of intrahepatic bile duct development and regeneration
This study is looking at how a protein called Sox9 helps liver cells grow and heal bile ducts, which could lead to new treatments for liver diseases that don't have many options right now.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10848457 on NIH RePORTER |
What this research studies
This research investigates the role of the Sox9 protein in the development and regeneration of bile ducts in the liver. By studying how Sox9 influences the behavior of liver cells, particularly during injury and disease, the research aims to uncover new insights into liver repair mechanisms. The approach includes using mouse models to observe the effects of Sox9 deficiency on bile duct formation and regeneration. This work could lead to the development of innovative therapies for liver diseases that currently have limited treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with liver diseases, particularly those related to bile duct dysfunction, such as Alagille Syndrome.
Not a fit: Patients with liver conditions unrelated to bile duct development or regeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver diseases, improving healing and regeneration of bile ducts.
How similar studies have performed: Previous research has shown that understanding the role of specific proteins like Sox9 can lead to significant advancements in regenerative medicine, indicating potential success for this approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Hrncir, Hannah Rose — Emory University
- Study coordinator: Hrncir, Hannah Rose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.