Understanding how small RNAs help bacteria survive acidic environments
Official title: Role of small RNAs in Streptococcus mutans acid stress response
Funded at University of Texas San Antonio · NIH-11067744 · Data updated 2026-11-12
This study is looking at how tiny molecules in a bacteria that causes cavities help it survive in acidic environments, which could lead to new ways to prevent and treat tooth decay.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | April 6, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $143,879 |
| NIH project number | 5R03DE033470-02 |
| Project ID | NIH-11067744 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are at risk for dental caries or have a history of dental decay.
✕Less likely to help
Patients who do not have dental caries or are not affected by acid-related dental issues may not benefit from this research.
What this research studies
This research investigates the role of small non-coding RNAs in the ability of Streptococcus mutans, a bacteria responsible for dental caries, to survive in acidic conditions. The researchers aim to identify specific small RNAs that help this bacteria resist acid stress, which could lead to new strategies for preventing and treating dental decay. By using genetic techniques and biochemical analyses, the study will explore how these small RNAs regulate the bacteria's response to acidity. This could ultimately provide insights into better dental health solutions.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for preventing and treating dental caries, improving oral health for many individuals.
How similar studies have gone: While the role of small RNAs in other bacteria has been studied, the specific application of this approach to Streptococcus mutans and its acid stress response is relatively novel.
Where this research is happening
-
University of Texas San Antonio
San Antonio, United States Active
Researchers
- Principal investigator: Raghavan, Rahul — University of Texas San Antonio
- Study coordinator: Raghavan, Rahul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.