Understanding how small blood vessel diseases affect oxygen supply in the brain
Investigating the Microvascular Mechanisms of O2 Supply-Demand Mismatch in Small Vessel Disease using Novel High-Resolution Optical Imaging
This study is looking at how problems with small blood vessels in the brain, especially in people with CADASIL, affect oxygen supply, using mice to help understand how these issues might lead to conditions like dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10831025 on NIH RePORTER |
What this research studies
This research investigates the relationship between small vessel diseases in the brain and oxygen supply issues, specifically focusing on a condition known as CADASIL. Using advanced optical imaging techniques, the study aims to measure oxygen levels, blood flow, and microvascular changes in a mouse model that mimics human disease. By observing these factors over time, researchers hope to uncover how dysfunction in small blood vessels contributes to oxygen supply-demand mismatches in the brain, which can lead to serious conditions like dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with CADASIL or other small vessel diseases affecting the brain.
Not a fit: Patients without small vessel diseases or those who do not have a genetic predisposition to conditions like CADASIL may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from small vessel diseases and related cognitive impairments.
How similar studies have performed: While this research explores a novel approach, previous studies have shown promising results in understanding microvascular dysfunction in other contexts.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sakadzic, Sava — Massachusetts General Hospital
- Study coordinator: Sakadzic, Sava
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.