Understanding how signaling proteins form complexes in cells
Official title: Natural and synthetic mechanisms of ligand formation
Funded at University of Texas Dallas · NIH-11080273 · Data updated 2026-11-12
This study is looking at how cells create important proteins that help them communicate with each other, which is key for healthy tissue development, and it could lead to new treatments for conditions where this communication goes wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project start | July 7, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $390,000 |
| NIH project number | 5R35GM150967-03 |
| Project ID | NIH-11080273 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions linked to signaling protein dysfunction or developmental disorders.
✕Less likely to help
Patients with conditions unrelated to cell signaling or those who do not have developmental issues may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells regulate the formation of signaling proteins that are crucial for communication within and between cells. It focuses on how these proteins assemble into complexes, which is essential for proper tissue development and function. By using a combination of embryological manipulation, biochemical techniques, and computational modeling, the research aims to uncover the molecular rules governing this assembly process. The findings could provide insights into how signaling goes awry in various conditions, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of conditions related to dysfunctional cell signaling.
How similar studies have gone: Other research has shown success in understanding signaling pathways and their implications in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Dallas
Richardson, United States Active
Researchers
- Principal investigator: Dingal, Polimyr Caesar Dave Pelisco — University of Texas Dallas
- Study coordinator: Dingal, Polimyr Caesar Dave Pelisco
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.