Understanding how SATB1 affects salivary gland development and function
Genome organizer SATB1 function in salivary gland and development and growth
This study is looking at a protein called SATB1 to understand how it helps salivary glands grow and work properly, especially for people who have issues with their saliva due to cancer treatments or autoimmune diseases, with the hope of finding new ways to help improve salivary gland function.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10757685 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called SATB1 in the development and function of salivary glands, which are crucial for oral health. The study aims to uncover how SATB1 regulates gene expression and cellular processes during the growth of salivary glands, particularly in the context of conditions that impair their function, such as cancer treatments and autoimmune diseases. By using genetic techniques in mice, researchers will trace the lineage of cells that express SATB1 and assess the impact of removing this protein on salivary gland cells. The ultimate goal is to identify potential therapeutic strategies for restoring salivary gland function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced salivary gland dysfunction due to cancer treatments or autoimmune diseases.
Not a fit: Patients without any history of salivary gland issues or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from impaired salivary gland function.
How similar studies have performed: While the specific role of SATB1 in salivary glands is less explored, similar research approaches have shown promise in understanding gene regulation in other tissues.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Kohwi-Shigematsu, Terumi — University of California, San Francisco
- Study coordinator: Kohwi-Shigematsu, Terumi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.