Understanding how SAMHD1 affects DNA repair in breast cancer cells
Elucidating SAMHD1 in DNA Double-Strand Break Repair
This study is looking at how a protein called SAMHD1 affects the way breast cancer cells fix their damaged DNA, which might help us find better treatments for patients whose tumors are hard to treat.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10977370 on NIH RePORTER |
What this research studies
This research investigates the role of SAMHD1 in the repair of DNA double-strand breaks (DSBs) in breast cancer cells. It aims to uncover how the dysregulation of DSB repair pathways contributes to treatment resistance in tumors. By studying the mechanisms of DSB repair, the research seeks to identify new molecular targets that could enhance the effectiveness of existing cancer treatments. Patients may benefit from improved therapies that specifically address the challenges posed by high SAMHD1 expression in their tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research include breast cancer patients, particularly those with high levels of SAMHD1 expression and those who have experienced treatment resistance.
Not a fit: Patients with cancers other than breast cancer or those without issues related to DNA repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for breast cancer patients who currently face challenges due to treatment resistance.
How similar studies have performed: Previous research has shown promising results in targeting DNA repair mechanisms in cancer, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Yu, David Sung-Wen — Emory University
- Study coordinator: Yu, David Sung-Wen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.