Understanding how SAMHD1 affects DNA repair in breast cancer cells
Elucidating SAMHD1 in DNA Double-Strand Break Repair
This study is looking at how a protein called SAMHD1 helps breast cancer cells fix their damaged DNA, with the hope of finding better treatments for patients who struggle with their current therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10977369 on NIH RePORTER |
What this research studies
This research investigates the role of SAMHD1 in the repair of DNA double-strand breaks (DSBs) in breast cancer cells. By examining how SAMHD1 influences the repair pathways that are often disrupted in tumors, the study aims to uncover new ways to overcome resistance to cancer treatments. The researchers will analyze the mechanisms by which SAMHD1 operates and how its expression levels correlate with patient outcomes. This could lead to improved therapeutic strategies for patients with breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those who have shown resistance to standard treatments.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for breast cancer by targeting the mechanisms of DNA repair.
How similar studies have performed: Previous research has shown promising results in targeting DNA repair mechanisms in cancer, suggesting that this approach may yield significant advancements.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Yu, David Sung-Wen — Emory University
- Study coordinator: Yu, David Sung-Wen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.