Understanding how SAMHD1 affects DNA repair in breast cancer cells
Elucidating SAMHD1 in DNA Double-Strand Break Repair
This study is looking at how a protein called SAMHD1 helps breast cancer cells fix broken DNA, with the hope of finding new ways to make treatments work better for patients whose tumors are hard to treat.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10894141 on NIH RePORTER |
What this research studies
This research investigates the role of SAMHD1 in the repair of DNA double-strand breaks (DSBs) in breast cancer cells. It aims to uncover how the dysregulation of DSB repair pathways contributes to treatment resistance in tumors. By studying the mechanisms of DSB repair, the research seeks to identify new molecular targets that could enhance the effectiveness of existing cancer treatments. Patients may benefit from insights that could lead to improved therapies for breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include breast cancer patients, especially those experiencing treatment resistance or with high levels of SAMHD1 expression.
Not a fit: Patients with cancers other than breast cancer or those not expressing SAMHD1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for breast cancer patients, particularly those who have developed resistance to current therapies.
How similar studies have performed: Previous research has shown promising results in targeting DNA repair mechanisms in cancer, suggesting that this approach may yield significant advancements.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Yu, David Sung-Wen — Emory University
- Study coordinator: Yu, David Sung-Wen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.