Understanding how Salmonella resists sulfite toxicity
Official title: Mechanistic evaluation of resistance to sulfite toxicity in Salmonella
Funded at University of Wisconsin-Madison · NIH-10861092 · Data updated 2026-11-12
This study looks at how the bacteria Salmonella can handle harmful substances called sulfites that it encounters during infections, focusing on a special protein that helps it survive, which could help us find better ways to fight foodborne illnesses caused by Salmonella.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | June 6, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $194,750 |
| NIH project number | 5R21AI178071-02 |
| Project ID | NIH-10861092 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced foodborne illnesses or are at risk of such infections.
✕Less likely to help
Patients who are not affected by bacterial infections or do not consume foods that may harbor Salmonella may not benefit from this research.
What this research studies
This research investigates how the bacteria Salmonella enterica can survive the toxic effects of sulfites, which are produced during bacterial infections. The study focuses on a specific protein, YeiE, that helps Salmonella manage sulfite levels, thereby aiding its survival and ability to cause disease. By examining the mechanisms of sulfite detoxification, the research aims to uncover new insights into bacterial behavior during infections. This could lead to a better understanding of how to combat foodborne illnesses caused by Salmonella.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating bacterial infections, particularly those caused by Salmonella.
How similar studies have gone: Previous research has shown that understanding bacterial resistance mechanisms can lead to significant advancements in treating infections, indicating potential success for this approach.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Elfenbein, Johanna Rebecca — University of Wisconsin-Madison
- Study coordinator: Elfenbein, Johanna Rebecca
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.