Understanding how Salmonella bacteria regulate their infection process
Novel sRNA-mediated regulation of Rho action at a 3' untranslated region to affect mRNA stability
This study is looking at how a type of bacteria called Salmonella Typhimurium manages to invade our intestines, which can cause serious stomach infections, and it aims to find new ways to prevent or treat these infections by understanding how the bacteria's genes work.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-11038890 on NIH RePORTER |
What this research studies
This research investigates how the Salmonella Typhimurium bacteria control their ability to invade the intestinal lining, which can lead to severe gastrointestinal infections. The focus is on a specific part of the bacteria's genetic material, known as the 3' untranslated region, which plays a crucial role in regulating the stability of mRNA, the molecule that carries genetic information. By exploring the interactions between various regulatory signals and the mRNA, the researchers aim to uncover new insights into bacterial behavior and infection mechanisms. This could lead to better strategies for preventing or treating infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of Salmonella infections, such as those with compromised immune systems or those in close contact with contaminated food sources.
Not a fit: Patients who are not affected by bacterial infections or who have no risk factors for Salmonella will likely not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or preventive measures for infections caused by Salmonella, improving patient outcomes.
How similar studies have performed: Other research has shown success in understanding bacterial regulation mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Slauch, James M. — University of Illinois at Urbana-Champaign
- Study coordinator: Slauch, James M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.