Understanding how Salmonella bacteria interact with human cells during infection
Official title: Decoding host-pathogen crosstalk that drives intracellular niche formation during Salmonella infection
Funded at University of Vermont & St Agric College · NIH-11036495 · Data updated 2026-11-12
This study is looking at how Salmonella bacteria manage to invade and live inside our intestinal cells, which could help us find better ways to treat infections, especially those that are hard to fight with antibiotics.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | November 15, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $204,347 |
| NIH project number | 1R21AI188037-01 |
| Project ID | NIH-11036495 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with Salmonella infections or are at high risk for such infections.
✕Less likely to help
Patients who are not affected by Salmonella infections or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates how Salmonella bacteria invade and survive within human intestinal cells, focusing on the different environments they create inside these cells. By using advanced techniques like fluorescent markers and RNA sequencing, the study aims to identify the specific responses of both the bacteria and the host cells during infection. This approach will help clarify how Salmonella can thrive in different cellular niches, which is crucial for developing better treatments. The findings could lead to new strategies for combating infections caused by antibiotic-resistant Salmonella.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections caused by antibiotic-resistant Salmonella, potentially reducing illness and death rates.
How similar studies have gone: Previous research has shown promise in understanding bacterial-host interactions, but this specific approach to studying Salmonella's intracellular behavior is relatively novel.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Knodler, Leigh — University of Vermont & St Agric College
- Study coordinator: Knodler, Leigh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.