Understanding how Salmonella affects gut bacteria
Microbiota outgrowth by Salmonella
This work explores how Salmonella infection changes the helpful bacteria in our gut and how these changes impact our health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11120849 on NIH RePORTER |
What this research studies
Our intestines are home to many different types of bacteria, which are important for our nutrition, immune system, and protection against harmful germs. However, certain bacteria like Salmonella can cause inflammation in the gut, disrupting this balance. This inflammation can actually help Salmonella grow while harming other beneficial bacteria. We are working to understand the specific ways Salmonella uses inflammation to its advantage and how these changes affect the gut environment and overall health.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients but focuses on understanding mechanisms relevant to individuals experiencing gut infections or imbalances.
Not a fit: Patients not experiencing gut infections or related inflammatory conditions may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat Salmonella infections and related gut imbalances.
How similar studies have performed: Research into the gut microbiome and pathogen interactions is an active field, with some studies showing success in identifying key mechanisms, but this specific approach to Salmonella's advantage during inflammation is a focused area of ongoing discovery.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Baumler, Andreas J — University of California at Davis
- Study coordinator: Baumler, Andreas J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.