Understanding how RNA modifications affect heart disease
RNA binding proteins in atherosclerosis
This study is looking at how certain proteins and their chemical changes might affect cholesterol levels and artery health, which could help us find new ways to treat heart disease, especially for those at risk of atherosclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11041622 on NIH RePORTER |
What this research studies
This research investigates the role of RNA binding proteins and their chemical modifications, specifically N6-methyladenosine (m6A), in the development of atherosclerosis, a major cause of cardiovascular disease. By using genetic models and therapeutic strategies, the researchers aim to understand how these RNA modifications influence cholesterol levels and the formation of arterial lesions. The study involves a multidisciplinary team working to uncover new mechanisms that could lead to innovative treatments for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
Not a fit: Patients who do not have risk factors for atherosclerosis or cardiovascular diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating atherosclerosis and related cardiovascular diseases.
How similar studies have performed: Other research has shown promising results in understanding RNA modifications in various diseases, suggesting potential for success in this novel approach to atherosclerosis.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Sallam, Tamer — University of California Los Angeles
- Study coordinator: Sallam, Tamer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.