Understanding how ribosomes control gene expression and stress responses
Translational Control: Discovery and Mechanisms
This study is looking at how tiny structures in our cells called ribosomes help control gene activity, especially when bacteria are under stress, and it aims to uncover how this knowledge could help us understand and potentially improve treatments for neurological disorders like ALS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11035138 on NIH RePORTER |
What this research studies
This research investigates the role of ribosomes in controlling gene expression, particularly how they respond to stress in bacteria and their implications for human neurodevelopment and neurological disorders. By using advanced techniques like cryo-electron microscopy, the research aims to characterize ribosome dynamics and interactions in both laboratory settings and complex cellular environments. The study will explore how ribosomes sense and respond to dysfunctional mRNAs, which is crucial for understanding diseases linked to translation dysregulation. Patients may benefit from insights gained into the mechanisms of diseases such as amyotrophic lateral sclerosis and other neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurological disorders, such as amyotrophic lateral sclerosis, or those affected by bacterial infections.
Not a fit: Patients with conditions unrelated to ribosomal function or those not experiencing neurological or bacterial issues may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological disorders and bacterial infections.
How similar studies have performed: Other research has shown success in understanding ribosomal functions and their implications in various diseases, indicating that this approach has potential for significant findings.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Korostelev, Andrei — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Korostelev, Andrei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.