Understanding how regulatory T cells help repair the nervous system during autoimmune diseases.
Tissue-Specific Mechanisms of Regulatory T Cells in the CNS during Autoimmune Encephalomyelitis
This study is looking at how special immune cells called regulatory T cells work in the spinal cord during autoimmune diseases like multiple sclerosis, with the hope that understanding their role can help improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11019701 on NIH RePORTER |
What this research studies
This research investigates the role of regulatory T cells in the central nervous system during autoimmune diseases like multiple sclerosis. By using advanced imaging techniques, the study aims to visualize how these cells behave and interact within the spinal cord to limit inflammation and promote tissue repair. The researchers will explore the specific environments, or niches, where these T cells operate, which could lead to new insights into treating autoimmune conditions. Patients may benefit from a better understanding of how their immune system can be regulated to improve outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune diseases, particularly those affecting the central nervous system, such as multiple sclerosis.
Not a fit: Patients with autoimmune conditions not affecting the central nervous system or those without autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the body's ability to repair nervous system damage caused by autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of regulatory T cells in other autoimmune conditions, suggesting potential for success in this area as well.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Othy, Shivashankar — University of California-Irvine
- Study coordinator: Othy, Shivashankar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.