Understanding how regulatory T cells control immune responses during infections
Specificity of regulatory T cell suppression during infection
['FUNDING_U01'] · UNIVERSITY OF CHICAGO · NIH-11073025
This study is looking at how special immune cells called regulatory T cells help keep your body safe from infections while also preventing them from attacking your own healthy tissues, which could lead to autoimmune diseases, and it aims to find new ways to improve treatments for these conditions.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11073025 on ClinicalTrials.gov |
What this research studies
This research investigates the role of regulatory T cells in managing the immune response to infections while preventing damage to the body's own tissues. It focuses on how these cells suppress self-reactive T cells that could lead to autoimmune diseases. By examining specific peptides recognized by regulatory T cells, the study aims to uncover the mechanisms that allow the immune system to distinguish between harmful pathogens and the body's own cells. This could lead to new insights into treating autoimmune conditions and improving immune responses during infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune conditions or those who are at risk of developing such disorders.
Not a fit: Patients with no autoimmune conditions or those not experiencing immune response issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases and better management of immune responses during infections.
How similar studies have performed: Previous research has shown promise in understanding T cell regulation, but this specific approach to studying regulatory T cells in the context of infections is relatively novel.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAVAGE, PETER AIDAN — UNIVERSITY OF CHICAGO
- Study coordinator: SAVAGE, PETER AIDAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease