Understanding how radiation affects blood vessel health in cancer patients
Official title: Unraveling the Role of p53 in Endothelium Homeostasis after Ionizing Radiation Exposure
Funded at Stanford University · NIH-10866250 · Data updated 2026-11-12
This study is looking at how radiation therapy affects the blood vessels of cancer patients, especially those at risk for heart problems caused by the treatment, and it aims to find out how certain genetic traits might change how their blood vessels respond to radiation, so we can improve their care.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 9, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $149,948 |
| NIH project number | 1K99HL173685-01 |
| Project ID | NIH-10866250 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who have undergone radiation therapy and have specific mutations in the TP53 gene.
✕Less likely to help
Patients who have not received radiation therapy or do not have TP53 mutations may not benefit from this research.
What this research studies
This research investigates the impact of radiation therapy on the health of blood vessels in cancer patients, particularly focusing on a condition known as radiation-induced coronary heart disease (RICHD). By using advanced techniques such as 3D models and human-induced pluripotent stem cells from patients with specific genetic mutations, the study aims to explore how these mutations influence the response of blood vessels to radiation. The research will involve both laboratory experiments and animal models to gain insights into the molecular changes that occur after radiation exposure. This comprehensive approach seeks to identify patient-specific risk factors that could help improve treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for minimizing heart-related side effects in cancer patients undergoing radiation therapy.
How similar studies have gone: Previous research has shown promising results in understanding the effects of radiation on vascular health, making this approach both relevant and potentially impactful.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Jahng, Won Suk — Stanford University
- Study coordinator: Jahng, Won Suk
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.