Understanding how PTEN signaling affects B cell development in the immune system
Official title: The role of PTEN signaling in regulating germinal center B cell fate decision
Funded at Indiana University Indianapolis · NIH-10875634 · Data updated 2026-11-12
This study is looking at how a specific signaling process in B cells, which are important for fighting infections and responding to vaccines, can be adjusted to make vaccines work better and help treat autoimmune diseases where the body makes harmful antibodies.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | June 26, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $198,125 |
| NIH project number | 5R21AI175824-02 |
| Project ID | NIH-10875634 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune disorders or those interested in the immune response to vaccines.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by B cell-related issues may not benefit from this research.
What this research studies
This research investigates the role of PTEN signaling in the fate decisions of germinal center B cells, which are crucial for generating memory B cells and long-lived plasma cells that help fight infections and respond to vaccines. The study aims to uncover how manipulating PTEN signaling can improve vaccine efficacy and treat autoimmune diseases caused by harmful antibodies. By examining the molecular mechanisms that guide B cells in their development, the research seeks to provide insights into better therapeutic strategies for managing autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases and enhanced vaccine responses.
How similar studies have gone: Previous research has shown promising results in manipulating B cell signaling pathways, indicating potential for success in this area.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Luo, Wei — Indiana University Indianapolis
- Study coordinator: Luo, Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.