Understanding how proteins recognize RNA and affect gene expression
Official title: Molecular mechanisms that regulate ADAR target recognition and RNA editing
Funded at Trustees of Indiana University · NIH-11011546 · Data updated 2026-11-12
This study is looking at how certain proteins in our bodies recognize and interact with specific types of RNA, which could help us understand their role in diseases and improve treatments tailored to individual patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | January 9, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $412,525 |
| NIH project number | 1R35GM156459-01 |
| Project ID | NIH-11011546 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by diseases linked to dysregulated RNA editing, particularly those involving ADAR proteins.
✕Less likely to help
Patients with conditions unrelated to RNA editing or those not involving ADAR proteins may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms by which ADAR proteins recognize double-stranded RNA (dsRNA) and how this recognition influences gene expression. By studying the interactions between RNA binding proteins and their targets, the research aims to uncover the biological functions and potential pathological consequences of these interactions. The approach involves examining the structural elements and sequences that guide these proteins in binding to RNA, which is crucial for understanding their role in various diseases. The findings could lead to advancements in personalized medicine by targeting RNA-level mutations.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for correcting genetic mutations at the RNA level, improving treatment options for patients with various diseases.
How similar studies have gone: Previous research has shown promising results in understanding RNA-protein interactions, suggesting that this approach could yield significant insights.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Hundley, Heather Ann — Trustees of Indiana University
- Study coordinator: Hundley, Heather Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.