Understanding how proteins interact to regulate gene activity
Official title: Deciphering Transcription Factor-Coregulator Interactions through Innovative Tools
Funded at Oregon Health & Science University · NIH-10937906 · Data updated 2026-11-12
This study is looking at how certain proteins work together to control genes, which is important for understanding diseases, and it's developing new tools to help researchers learn more about these interactions so that patients can benefit from better insights into their health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $390,000 |
| NIH project number | 1R35GM154834-01 |
| Project ID | NIH-10937906 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to gene regulation, such as metabolic disorders or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to gene regulation or those not affected by transcription factor interactions may not benefit from this research.
What this research studies
This research focuses on the interactions between transcription factors and their coregulators, which are crucial for gene regulation and cellular differentiation. By developing innovative tools, such as DNA barcode methods, the research aims to improve the study of these protein complexes, which play a significant role in various diseases. The approach includes using advanced techniques to enhance the specificity and reliability of protein interaction data, ultimately leading to a better understanding of how disruptions in these interactions can contribute to health issues. Patients may benefit from insights gained into the molecular mechanisms underlying their conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating diseases linked to gene regulation.
How similar studies have gone: Other research has shown promise in using innovative proteomics methods to study protein interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Mohammed, Hisham — Oregon Health & Science University
- Study coordinator: Mohammed, Hisham
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.