Understanding how proteins interact and their roles in diseases
Computational and Experimental Investigation and Design of Protein Interaction Specificity
This study is looking at how proteins in our cells work together and how these interactions can change when someone has cancer, with the goal of finding new ways to treat diseases by understanding and possibly changing these protein connections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11092108 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between proteins that are crucial for cellular functions and how these interactions can change in diseases like cancer. By combining computational methods and experimental techniques, the study aims to map the human interactome, which is the network of protein interactions, and identify specific binding motifs that play significant roles in cellular signaling and structure. The research will also explore how to inhibit or modulate these interactions to develop new therapeutic strategies. Patients may benefit from insights gained about protein interactions that could lead to innovative treatments for various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein interaction abnormalities, such as cancer or other diseases influenced by cellular signaling.
Not a fit: Patients with conditions unrelated to protein interactions or those not involving cellular signaling pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that target specific protein interactions involved in diseases, potentially improving treatment outcomes for patients.
How similar studies have performed: Other research has shown success in understanding protein interactions and their implications in diseases, indicating that this approach has potential for significant advancements.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Keating, Amy E — Massachusetts Institute of Technology
- Study coordinator: Keating, Amy E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.