Understanding how proteins control actin filament networks in cells
Control of actin filament networks by Arp2/3 complex and its regulators
['FUNDING_OTHER'] · UNIVERSITY OF OREGON · NIH-11085873
This study is looking at how certain proteins help control the building blocks of cell movement and division, which is important for healthy cells and understanding diseases like cancer and infections, using special imaging techniques to see how these proteins work in real time.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OREGON (nih funded) |
| Locations | 1 site (EUGENE, UNITED STATES) |
| Trial ID | NIH-11085873 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Arp2/3 complex and its regulatory proteins in controlling actin filament networks, which are crucial for various cellular processes such as movement and division. By using advanced techniques like live cell imaging and molecular simulations, the researchers aim to uncover how these proteins activate the Arp2/3 complex and how this activation influences cellular functions. The findings could provide insights into both normal cellular activities and disease processes, such as cancer metastasis and bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions involving abnormal cell movement, such as cancer patients or those with bacterial infections.
Not a fit: Patients with conditions unrelated to cell motility or those not affected by cancer or bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cell movement, including cancer and bacterial infections.
How similar studies have performed: Other research has shown success in understanding actin dynamics and its implications in various diseases, suggesting that this approach has potential for impactful findings.
Where this research is happening
EUGENE, UNITED STATES
- UNIVERSITY OF OREGON — EUGENE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NOLEN, BRADLEY J — UNIVERSITY OF OREGON
- Study coordinator: NOLEN, BRADLEY J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections, cancer metastasis, Cancerous