Understanding how proteins communicate through allosteric signals
Official title: Librational Mode Coupling Theory of Allosteric Signal Transmission
Funded at Wesleyan University · NIH-10360233 · Data updated 2026-11-12
This study is looking at how proteins behave differently when they interact with other molecules or when they have certain changes, which is important for things like metabolism and how genes work, and it hopes to help improve drug design and our understanding of diseases caused by protein issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wesleyan University NIH-funded |
| Lab location | 1 site (Middletown, United States) |
| Project start | May 3, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2022 |
| Award (this year) | $482,490 |
| NIH project number | 1R15GM144870-01 |
| Project ID | NIH-10360233 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting protein function or those with conditions related to metabolic control.
✕Less likely to help
Patients with conditions unrelated to protein function or allosteric signaling may not benefit from this research.
What this research studies
This research investigates how proteins change their behavior when influenced by other molecules or mutations. It focuses on the allosteric effect, which is crucial for many biological processes, including metabolism and gene expression. By using advanced computer simulations, the study aims to uncover the mechanisms behind these interactions and how they affect protein function. This could lead to better drug design and understanding of diseases related to protein malfunction.
Why it matters
Potential benefit: If successful, this research could lead to improved drug designs that target specific protein functions more effectively.
How similar studies have gone: While there have been some successful studies exploring allosteric effects, this research aims to provide a novel approach using advanced computational methods.
Where this research is happening
-
Wesleyan University
Middletown, United States Active
Researchers
- Principal investigator: Beveridge, David Lewis — Wesleyan University
- Study coordinator: Beveridge, David Lewis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.