Investigating how bacteria break down protective biofilms to disperse.
Official title: Structural and functional studies of glycosyl hydrolases governing Vibrio biofilm dispersal
Funded at Wesleyan University · NIH-10795423 · Data updated 2026-11-12
This study is looking at how a specific bacteria, Vibrio cholerae, creates protective layers that help it survive against antibiotics, and by understanding how these layers break apart, we hope to find better ways to treat infections for patients dealing with antibiotic-resistant bacteria.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wesleyan University NIH-funded |
| Lab location | 1 site (Middletown, United States) |
| Project start | September 6, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $471,243 |
| NIH project number | 1R15GM152959-01 |
| Project ID | NIH-10795423 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by biofilm-forming bacteria, particularly those resistant to standard antibiotic treatments.
✕Less likely to help
Patients with infections caused by non-biofilm-forming bacteria may not receive any benefit from this research.
What this research studies
This research focuses on understanding how certain bacteria, specifically Vibrio cholerae, form and disperse biofilms, which are protective layers that shield them from antibiotics and the immune system. By examining the molecular mechanisms involved in biofilm dispersal, the research aims to identify key proteins, such as RbmB, that help break down the biofilm matrix. This knowledge could lead to new strategies for treating infections caused by antibiotic-resistant bacteria. Patients may benefit from improved treatments for bacterial infections as a result of this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively combat antibiotic-resistant bacterial infections.
How similar studies have gone: Other research has shown promise in understanding biofilm dynamics and has led to advancements in treating biofilm-related infections, indicating that this approach has potential for success.
Where this research is happening
-
Wesleyan University
Middletown, United States Active
Researchers
- Principal investigator: Olson, Richard a — Wesleyan University
- Study coordinator: Olson, Richard a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.