Understanding how proteins are made in nerve cell branches
Mechanisms of Local Protein Synthesis in Axon Arborization
['FUNDING_R01'] · UNIVERSITY OF NEVADA RENO · NIH-10819582
This study is looking at how nerve cells make important proteins, especially one called CPEB, which helps control the production of another protein related to brain disorders, using fruit flies to learn more about how these processes work and how problems with them might lead to neurological issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEVADA RENO (nih funded) |
| Locations | 1 site (RENO, UNITED STATES) |
| Trial ID | NIH-10819582 on ClinicalTrials.gov |
What this research studies
This research investigates how proteins are synthesized locally in the branches of nerve cells, which is crucial for their proper functioning. The study focuses on a specific protein, CPEB, and its role in regulating the synthesis of another protein linked to brain disorders. Using the fruit fly as a model organism, researchers will explore the mechanisms that control protein production in axons, which are the long extensions of nerve cells. By understanding these processes, the research aims to shed light on how disruptions in protein synthesis can lead to various neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may be related to axonal protein synthesis issues.
Not a fit: Patients with conditions unrelated to axonal function or protein synthesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of brain disorders linked to protein synthesis dysfunction.
How similar studies have performed: While the specific approach of studying local protein synthesis in axons is innovative, similar research has shown promise in understanding protein synthesis in other cellular contexts.
Where this research is happening
RENO, UNITED STATES
- UNIVERSITY OF NEVADA RENO — RENO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, JUNG HWAN — UNIVERSITY OF NEVADA RENO
- Study coordinator: KIM, JUNG HWAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Disorders, Encephalon Diseases, Intracranial CNS Disorders, Intracranial Central Nervous System Disorders, Brain Diseases