Understanding how proteins are broken down in cells
Official title: Defining the Function of Proteasomal Deubiquitinases
Funded at University of Massachusetts Amherst · NIH-10852875 · Data updated 2026-11-12
This study is looking at how certain enzymes help control the breakdown of proteins in our cells, which is important for keeping us healthy, and it could lead to new treatments for diseases like cancer and neurological disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $393,414 |
| NIH project number | 5R35GM149532-02 |
| Project ID | NIH-10852875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with certain cancers or neurological disorders where protein degradation is misregulated.
✕Less likely to help
Patients with conditions unrelated to protein degradation or those not diagnosed with cancer or neurological disorders may not benefit from this research.
What this research studies
This research investigates the role of specific enzymes called deubiquitinases in regulating the degradation of proteins by the 26S proteasome, a crucial cellular component responsible for protein breakdown. By using advanced techniques like x-ray crystallography and cell-based approaches, the research aims to uncover how these enzymes influence protein degradation, which is vital for maintaining cellular health. The findings could lead to the development of new drugs targeting these regulatory mechanisms, particularly for conditions like cancer and neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for various cancers and neurological disorders by targeting the mechanisms of protein degradation.
How similar studies have gone: Previous research has shown promising results in targeting proteasomal pathways for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of Massachusetts Amherst
Hadley, United States Active
Researchers
- Principal investigator: Strieter, Eric Robert — University of Massachusetts Amherst
- Study coordinator: Strieter, Eric Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.