Understanding how protein regulation affects cell division
Official title: Proteostasis signaling in cell cycle control
Funded at Univ of North Carolina Chapel Hill · NIH-11055986 · Data updated 2026-11-12
This study is looking at how certain proteins help control cell division, which is important for understanding diseases like cancer, and it aims to find new ways to treat these conditions by figuring out how proteins are broken down in our cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $581,076 |
| NIH project number | 5R35GM153250-02 |
| Project ID | NIH-11055986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or conditions related to cell cycle dysregulation.
✕Less likely to help
Patients with conditions unrelated to cell cycle control or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research investigates the role of protein dynamics in controlling the cell cycle, focusing on how proteins like cyclins and cyclin kinase inhibitors regulate cell division. By studying the ubiquitin proteasome system, which is crucial for protein degradation, the research aims to identify specific enzymes that influence when and how proteins are marked for degradation. This understanding could lead to insights into how cell cycle progression is maintained and how disruptions may lead to diseases like cancer. Patients may benefit from findings that could inform new therapeutic strategies targeting cell cycle regulation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers by targeting the mechanisms that control cell division.
How similar studies have gone: Previous research has shown that targeting the ubiquitin proteasome system can be effective in cancer treatment, indicating potential success for this approach.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Emanuele, Michael James — Univ of North Carolina Chapel Hill
- Study coordinator: Emanuele, Michael James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.