Understanding how protein changes drive aging
Investigating protein supersaturation as a driver of aging
This study is looking at how certain proteins clump together as we get older and how that might contribute to aging and related health issues, with the goal of finding new ways to help people stay healthier as they age.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stowers Institute for Medical Research NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11076249 on NIH RePORTER |
What this research studies
This research investigates the role of protein aggregation in the aging process and age-related diseases. By examining how certain proteins become supersaturated and lead to cellular aging, the study aims to identify fundamental mechanisms that could be targeted for new therapies. The approach includes analyzing human fibroblasts from donors of various ages to understand the relationship between protein behavior and biological age. Techniques such as RNA sequencing and epigenetic clocks will be employed to gather insights into protein stability and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or those interested in understanding the biological mechanisms of aging.
Not a fit: Patients who are young and do not exhibit any signs of age-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that slow down the aging process and improve health in older adults.
How similar studies have performed: While the investigation of protein aggregation in aging is a well-studied area, the specific approach of examining supersaturation and its direct effects on aging is relatively novel.
Where this research is happening
Kansas City, United States
- Stowers Institute for Medical Research — Kansas City, United States (Active)
Researchers
- Principal investigator: Von Schulze, Alex — Stowers Institute for Medical Research
- Study coordinator: Von Schulze, Alex
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.