Understanding how prostate tumors develop and change over time
Official title: Investigating luminal plasticity in prostate tumorigenesis
Funded at State University New York Stony Brook · NIH-11096091 · Data updated 2026-11-12
This study is looking at how certain cells in the prostate can change as we age, which might lead to issues like benign prostate enlargement and prostate cancer, and it aims to find ways to help treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | May 28, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $355,625 |
| NIH project number | 5R01CA292863-02 |
| Project ID | NIH-11096091 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult men, particularly those over 21 years old, who may be at risk for prostate disorders due to age.
✕Less likely to help
Patients who are not male or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the cellular and molecular mechanisms that contribute to prostate disorders, particularly benign prostate enlargement and prostate cancer, which are linked to aging. The study focuses on understanding the role of specific cell types and signaling pathways that may lead to uncontrolled cell growth in the prostate. By analyzing prostate tissue samples from both aged mice and humans, the research aims to uncover how certain cells contribute to the maintenance of normal prostate function and how their dysregulation can lead to cancer. This could provide insights into potential therapeutic targets for prostate cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating prostate cancer, improving outcomes for patients.
How similar studies have gone: Previous research has shown promise in understanding prostate cancer through cellular mechanisms, but this specific approach focusing on luminal plasticity is relatively novel.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Talos, Flaminia — State University New York Stony Brook
- Study coordinator: Talos, Flaminia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.