Understanding how prion proteins are processed in the brain
Mapping Molecular Pathways that Control Prion Metabolism
['FUNDING_R37'] · DARTMOUTH COLLEGE · NIH-10912446
This study is looking at how prion proteins, which are connected to serious brain diseases, are made and broken down in our cells, with the hope that understanding this process will help find new treatments for patients affected by these conditions.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-10912446 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular pathways involved in the metabolism of prion proteins, which are linked to serious neurodegenerative diseases like Creutzfeldt-Jakob disease and Chronic Wasting Disease. By utilizing advanced techniques such as CRISPR and fluorescence-activated cell sorting, the study aims to identify how these proteins are synthesized, transported, and degraded within cells. The findings could lead to a better understanding of prion diseases and highlight potential targets for new drug therapies. Patients may benefit from insights gained that could inform future treatment options.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals affected by prion diseases such as Creutzfeldt-Jakob disease or Chronic Wasting Disease.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by prion diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating prion-related neurodegenerative diseases.
How similar studies have performed: Previous research has shown promise in understanding prion biology, but this approach using CRISPR for mapping molecular pathways is relatively novel.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUPATTAPONE, SURACHAI — DARTMOUTH COLLEGE
- Study coordinator: SUPATTAPONE, SURACHAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders