Understanding how potassium channels work in cells
Official title: Structural Basis of Coupling and Dynamics in K+ Channels
Funded at University of Chicago · NIH-10931367 · Data updated 2026-11-12
This study looks at how potassium channels in our cells work and change shape when they respond to electrical signals, which is important for heart and brain health, and it hopes to find new ways to help people with conditions like heart rhythm problems and epilepsy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 20, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $501,478 |
| NIH project number | 5R01GM150272-02 |
| Project ID | NIH-10931367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions linked to potassium channel dysfunction, such as those experiencing cardiac arrhythmias or seizure disorders.
✕Less likely to help
Patients with conditions unrelated to potassium channel function or those not experiencing electrical activity disorders may not benefit from this research.
What this research studies
This research investigates the structural and dynamic properties of potassium (K+) channels, which are crucial for regulating electrical activity in cells. By examining how these channels change shape in response to electrical signals, the study aims to uncover the molecular mechanisms behind their function. The research employs advanced techniques such as cryo-electron microscopy to visualize the channels in different states, providing insights into their role in conditions like cardiac arrhythmia and epilepsy. Patients may benefit from a deeper understanding of these channels, potentially leading to new treatments for related disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to potassium channel dysfunction, such as cardiac arrhythmias and epilepsy.
How similar studies have gone: Other research has shown success in understanding ion channel dynamics, indicating that this approach has the potential for significant findings.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Perozo, Eduardo a — University of Chicago
- Study coordinator: Perozo, Eduardo a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.