Understanding how podocyte damage occurs in Alport Syndrome
Mechanisms involved in podocyte damage in Alport Syndrome
This study is looking into how kidney cells called podocytes get damaged in Alport Syndrome, with the goal of finding ways to help them survive better, which could lead to new treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11098508 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind podocyte damage in Alport Syndrome, a condition that affects kidney function. By utilizing advanced models, including a glomerulus-on-a-chip platform and specialized mouse models, the research aims to identify how podocytes interact with their environment and how their survival can be improved. The study focuses on specific molecular pathways that could be targeted to slow down or potentially reverse kidney disease progression. Patients may benefit from insights that could lead to new treatment strategies for Alport Syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alport Syndrome or related hereditary nephritis conditions.
Not a fit: Patients with kidney diseases unrelated to podocyte damage or those without a diagnosis of Alport Syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow or reverse kidney damage in patients with Alport Syndrome.
How similar studies have performed: Previous research has shown promise in targeting molecular pathways in kidney diseases, suggesting that this approach could yield significant advancements.
Where this research is happening
Los Angeles, United States
- Children's Hospital of Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Perin, Laura — Children's Hospital of Los Angeles
- Study coordinator: Perin, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.