Understanding how pneumonia affects recovery after spinal cord injury
Official title: Protecting endogenous recovery from the "infectious insult" in Spinal Cord Injury
Funded at Ohio State University · NIH-10981536 · Data updated 2026-11-12
This study is looking at how pneumonia affects recovery after a spinal cord injury, using mice to see if the infection makes healing harder and to find ways to help protect the nervous system during recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $566,089 |
| NIH project number | 1R01NS135237-01A1 |
| Project ID | NIH-10981536 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a spinal cord injury and are at risk of developing pneumonia.
✕Less likely to help
Patients who have not experienced a spinal cord injury or those without a risk of pneumonia may not benefit from this research.
What this research studies
This research investigates the impact of pneumonia on recovery following spinal cord injury (SCI). By using a mouse model, the study aims to determine if pneumonia directly worsens neurological recovery by analyzing the interactions between the immune response and the injured spinal cord. The researchers will explore how bacterial infections influence the healing process and identify potential neuroprotective interventions. This work employs advanced techniques to visualize and understand the underlying mechanisms of injury and repair.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies for patients with spinal cord injuries who develop pneumonia.
How similar studies have gone: Previous research has shown that infections can significantly impact recovery in various conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Schwab, Jan — Ohio State University
- Study coordinator: Schwab, Jan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.