Understanding how pleural mesothelial cells affect lung injury and healing
The role of pleural mesothelium in lung injury, repair, and regeneration
['FUNDING_FELLOWSHIP'] · MAYO CLINIC ROCHESTER · NIH-10994989
This study is looking at special cells in the lungs called pleural mesothelial cells to understand how they help with lung injury and healing, which could lead to better treatments for lung diseases like idiopathic pulmonary fibrosis.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10994989 on ClinicalTrials.gov |
What this research studies
This research investigates the role of pleural mesothelial cells (PMCs) in the processes of lung injury, repair, and regeneration. By studying these cells in mouse models, the research aims to clarify their functions, which are currently poorly understood and sometimes contradictory. The project will explore how PMCs respond to lung damage and whether they can aid in healing or contribute to fibrosis. This could lead to new insights into lung diseases and potential therapeutic approaches for conditions like idiopathic pulmonary fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults suffering from lung diseases, particularly those with conditions characterized by fibrosis or impaired lung repair.
Not a fit: Patients with acute lung injuries that do not involve fibrotic processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote lung repair and regeneration, improving outcomes for patients with lung diseases.
How similar studies have performed: While there is some existing research on lung repair mechanisms, the specific focus on pleural mesothelial cells in this context is relatively novel and has not been extensively tested.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GILBERT, RACHEL — MAYO CLINIC ROCHESTER
- Study coordinator: GILBERT, RACHEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.