Understanding how pleural mesothelial cells affect lung injury and healing
Official title: The role of pleural mesothelium in lung injury, repair, and regeneration
Funded at Mayo Clinic Rochester · NIH-10994989 · Data updated 2026-11-12
This study is looking at special cells in the lungs called pleural mesothelial cells to understand how they help with lung injury and healing, which could lead to better treatments for lung diseases like idiopathic pulmonary fibrosis.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32HL175907-01 |
| Project ID | NIH-10994989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from lung diseases, particularly those with conditions characterized by fibrosis or impaired lung repair.
✕Less likely to help
Patients with acute lung injuries that do not involve fibrotic processes may not benefit from this research.
What this research studies
This research investigates the role of pleural mesothelial cells (PMCs) in the processes of lung injury, repair, and regeneration. By studying these cells in mouse models, the research aims to clarify their functions, which are currently poorly understood and sometimes contradictory. The project will explore how PMCs respond to lung damage and whether they can aid in healing or contribute to fibrosis. This could lead to new insights into lung diseases and potential therapeutic approaches for conditions like idiopathic pulmonary fibrosis.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote lung repair and regeneration, improving outcomes for patients with lung diseases.
How similar studies have gone: While there is some existing research on lung repair mechanisms, the specific focus on pleural mesothelial cells in this context is relatively novel and has not been extensively tested.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Gilbert, Rachel — Mayo Clinic Rochester
- Study coordinator: Gilbert, Rachel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.