Understanding how platelets function in blood clotting and inflammation
Pathway maps of platelet phenotype and function
This study is looking at how different types of platelets, which help stop bleeding, act in both healthy and inflamed conditions, especially in heart-related diseases, to find better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10599257 on NIH RePORTER |
What this research studies
This research investigates the role of platelets, which are crucial for stopping bleeding, in both normal and inflammatory conditions. It aims to identify how different platelet types behave in response to various signals in the body, particularly in relation to diseases like atherosclerosis. By examining the internal signaling pathways that control platelet actions such as adhesion, secretion, and aggregation, the study seeks to clarify how these processes differ in healthy versus diseased states. This could lead to targeted therapies that improve patient outcomes in cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cardiovascular diseases, particularly those experiencing issues related to platelet function and vascular inflammation.
Not a fit: Patients without cardiovascular conditions or those not experiencing platelet-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage cardiovascular diseases by targeting specific platelet functions.
How similar studies have performed: Previous research has shown promise in understanding platelet functions and their implications in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Aslan, Joseph E — Oregon Health & Science University
- Study coordinator: Aslan, Joseph E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.