Understanding how past kidney injuries affect pregnancy outcomes in women
Official title: Mechanisms of subclinical renal injury in females following AKI: implications for adverse pregnancy outcomes
Funded at Augusta University · NIH-11030330 · Data updated 2026-11-12
This study looks at how having a serious kidney injury can affect pregnancy outcomes in women, using rats to help understand how kidney health influences things like baby weight and overall health during pregnancy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | February 8, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $406,991 |
| NIH project number | 5R01DK134695-03 |
| Project ID | NIH-11030330 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have experienced acute kidney injury and are planning to conceive or are currently pregnant.
✕Less likely to help
Patients who have not experienced acute kidney injury or those who are not planning to conceive may not benefit from this research.
What this research studies
This research investigates the long-term effects of acute kidney injury (AKI) on pregnancy outcomes in women. It uses a rat model to simulate the conditions of pregnancy following AKI, focusing on how kidney function impacts the body's ability to adapt during pregnancy. The study aims to uncover the mechanisms that lead to adverse outcomes, such as low birth weight, by examining factors like nitric oxide availability and immune responses. By understanding these processes, the research seeks to improve maternal and fetal health for women with a history of AKI.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for pregnant women with a history of acute kidney injury, potentially improving outcomes for both mothers and their babies.
How similar studies have gone: Other research has indicated that understanding the mechanisms of kidney injury and its effects on pregnancy can lead to significant advancements in maternal-fetal medicine.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Sullivan, Jennifer C — Augusta University
- Study coordinator: Sullivan, Jennifer C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.