Understanding how past experiences influence behavior in the brain
Official title: In vivo mechanisms for integration of contextual information
Funded at Fred Hutchinson Cancer Center · NIH-10897734 · Data updated 2026-11-12
This study looks at how our brains use past experiences to shape our actions, especially in people with neurological and mental disorders, by exploring a tiny worm called C. elegans to understand the genes and signals involved in this process.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $44,503 |
| NIH project number | 5F31NS129545-02 |
| Project ID | NIH-10897734 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological or mental disorders that affect their ability to use contextual information in daily life.
✕Less likely to help
Patients without neurological or mental disorders may not receive direct benefits from this research.
What this research studies
This research investigates how the brain uses contextual information from past experiences to influence behavior, particularly in the context of neurological and mental disorders. By studying the simple organism C. elegans, the research aims to uncover the molecular and circuit mechanisms that enable context-dependent behavior. The approach involves examining specific genes and signaling pathways, particularly focusing on cyclic GMP signals and their role in modulating neural circuit activity. The findings could provide insights into how disruptions in these processes affect behavior and social interactions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for individuals with neurological and mental disorders, enhancing their ability to navigate social and physical environments.
How similar studies have gone: While the specific approach using C. elegans is novel, similar studies have shown success in understanding behavioral modulation through genetic and molecular mechanisms in other model organisms.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Rosero, Manuel — Fred Hutchinson Cancer Center
- Study coordinator: Rosero, Manuel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.