Understanding how p53 affects immune responses and cancer development
Official title: ELUCIDATING THE FUNCTION OF P53-MEDIATED IL17RB REPRESSION
Funded at St. John's University · NIH-10796206 · Data updated 2026-11-12
This study is looking at how a protein called p53 helps control another protein linked to inflammation and cancer, with the hope of finding new ways to fight these diseases and improve treatments for people affected by them.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. John's University NIH-funded |
| Lab location | 1 site (Queens, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $492,000 |
| NIH project number | 1R15CA287406-01 |
| Project ID | NIH-10796206 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancers associated with IL17RB dysregulation or those experiencing inflammatory conditions.
✕Less likely to help
Patients with cancers or inflammatory conditions unrelated to IL17RB or p53 pathways may not benefit from this research.
What this research studies
This research investigates the role of the p53 tumor suppressor in regulating the Interleukin 17 Receptor B (IL17RB), which is linked to inflammation and cancer. By examining how p53 represses IL17RB, the study aims to uncover mechanisms that could enhance tumor suppression and reduce inflammation. The researchers will use various biochemical and cellular techniques to analyze gene expression and the effects of p53 activation on immune responses. This work could provide insights into new therapeutic strategies for cancer and inflammatory diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cancer outcomes and reduce inflammation in patients.
How similar studies have gone: Previous research has shown promising results in targeting immune pathways for cancer treatment, suggesting potential success for this approach.
Where this research is happening
-
St. John's University
Queens, United States Active
Researchers
- Principal investigator: Zhu, Yan — St. John's University
- Study coordinator: Zhu, Yan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.