Understanding how ozone exposure affects lung injury in sepsis patients
Role of Macrophage Efferocytosis in Ozone-Induced ARDS
This study is looking at how breathing in ozone might make lung problems worse for people who have serious infections, like sepsis, by affecting how their immune cells clean up dead cells in the lungs, and it hopes to find out why some people get sicker than others.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10909093 on NIH RePORTER |
What this research studies
This research investigates the connection between ozone exposure and the development of acute respiratory distress syndrome (ARDS) in patients who have experienced systemic infections like sepsis. The study focuses on how the body's immune cells, specifically macrophages, manage dead cells in the lungs and how this process may be impaired by ozone. By using a novel experimental model with mice, researchers aim to uncover the mechanisms that lead to increased inflammation and lung injury following ozone exposure, particularly in individuals with certain genetic factors. The findings could help identify why some patients develop ARDS while others do not.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced sepsis and are exposed to high levels of ozone or other air pollutants.
Not a fit: Patients who do not have a history of sepsis or significant exposure to ozone may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for patients at risk of developing ARDS due to environmental factors.
How similar studies have performed: Previous research has shown that environmental factors like air pollution can influence respiratory conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Radbel, Jared M. — Rutgers Biomedical and Health Sciences
- Study coordinator: Radbel, Jared M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.