Understanding how oxidative stress activates immune responses
Redox control of the NLRP1 inflammasome
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11089424
This study is looking at how parts of your immune system called inflammasomes react to stress in your cells, especially focusing on two specific types, NLRP1 and CARD8, to better understand how they might contribute to inflammation and help find new ways to treat autoimmune diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11089424 on ClinicalTrials.gov |
What this research studies
This research investigates how certain immune system components, known as inflammasomes, respond to signals of cellular stress, particularly focusing on the NLRP1 and CARD8 inflammasomes. The researchers aim to uncover the role of reactive oxygen species in activating these inflammasomes, which are crucial for triggering inflammatory cell death. By exploring the interaction between oxidative stress and specific inhibitors, the study seeks to clarify the mechanisms behind immune activation and inflammation. This could lead to new insights into treating autoimmune diseases and other related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune conditions or diseases characterized by dysregulated inflammation.
Not a fit: Patients with non-autoimmune conditions or those not experiencing inflammatory responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing autoimmune diseases by targeting the mechanisms of inflammation.
How similar studies have performed: Previous research has shown success in understanding inflammasome activation, but the specific focus on reductive stress as a danger signal is a novel approach.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BACHOVCHIN, DANIEL — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: BACHOVCHIN, DANIEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease