Understanding how nucleolar structures control human embryonic stem cell development
Official title: A Nucleolar Paradigm for Pluripotency of Human Embryonic Stem Cells
Funded at Columbia University Health Sciences · NIH-11010870 · Data updated 2026-11-12
This study is looking at how certain tiny structures in cells help keep human embryonic stem cells in a state where they can become any type of cell, which is important for understanding how to use these cells in medicine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 12, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $486,246 |
| NIH project number | 5R01HD114122-02 |
| Project ID | NIH-11010870 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions that could be treated through advancements in stem cell therapies.
✕Less likely to help
Patients with conditions unrelated to stem cell biology or those who are not candidates for stem cell therapies may not receive benefit from this research.
What this research studies
This research investigates the role of nucleolar structures in maintaining the pluripotency of human embryonic stem cells. It focuses on how the integrity of these structures influences ribosome biogenesis and gene expression, which are crucial for stem cell function. By utilizing advanced technologies to study the nucleolus and its interactions with proteins and RNA, the research aims to uncover new mechanisms that govern stem cell behavior. This could lead to a better understanding of stem cell biology and its applications in regenerative medicine.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of stem cell development and improve strategies for regenerative therapies.
How similar studies have gone: While the role of nucleolar structures in stem cell biology is an emerging field, similar approaches have shown promise in understanding cellular mechanisms, indicating potential for success.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Wang, Jianlong — Columbia University Health Sciences
- Study coordinator: Wang, Jianlong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.